Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

How NMDAR and GABA neuronal dysfunctions result in impaired social behaviour is unclear. Here, the authors show that NMDARs and gap junctions in cortical PV interneurons modulate burst firing, affecting social behaviour.

Bibliographic Details
Main Authors: Eunee Lee, Seungjoon Lee, Jae Jin Shin, Woochul Choi, Changuk Chung, Suho Lee, Jihye Kim, Seungmin Ha, Ryunhee Kim, Taesun Yoo, Ye-Eun Yoo, Jisoo Kim, Young Woo Noh, Issac Rhim, Soo Yeon Lee, Woohyun Kim, Taekyung Lee, Hyogeun Shin, Il-Joo Cho, Karl Deisseroth, Sang Jeong Kim, Joo Min Park, Min Whan Jung, Se-Bum Paik, Eunjoon Kim
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25356-2

Internet

https://doi.org/10.1038/s41467-021-25356-2

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