LALAPG variant of the Human Contraception Antibody (HCA) reduces Fc-mediated effector functions while maintaining sperm agglutination activity.

LALAPG variant of the Human Contraception Antibody (HCA) reduces Fc-mediated effector functions while maintaining sperm agglutination activity.

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High rates of unintended pregnancies worldwide indicate a need for more accessible and acceptable methods of contraception. We have developed a monoclonal antibody, the Human Contraception Antibody (HCA), for use by women in vaginal films and rings for contraception. The divalent F(ab')2 region...

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Bibliographic Details
Main Authors: Emilie Mausser, Ellena Nador, Joseph A Politch, Michael R Pauly, Jai G Marathe, Thomas R Moench, Larry Zeitlin, Kevin J Whaley, Deborah J Anderson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0282147

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https://doi.org/10.1371/journal.pone.0282147

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