SFRP4 Expression Is Linked to Immune-Driven Fibrotic Conditions, Correlates with Skin and Lung Fibrosis in SSc and a Potential EMT Biomarker

SFRP4 Expression Is Linked to Immune-Driven Fibrotic Conditions, Correlates with Skin and Lung Fibrosis in SSc and a Potential EMT Biomarker

Secreted Frizzled Receptor Protein 4 (SFRP4) has been shown to be increased in Scleroderma (SSc). To determine its role in immune-driven fibrosis, we analysed SSc and sclerotic Chronic Graft Versus Host Disease (sclGVHD) biosamples; skin biopsies (<i>n</i> = 24) from chronic GVHD patient...

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Bibliographic Details
Main Authors: Ilaria Tinazzi, Panji Mulipa, Chiara Colato, Giuseppina Abignano, Andrea Ballarin, Domenico Biasi, Paul Emery, Rebecca L. Ross, Francesco Del Galdo
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Journal of Clinical Medicine
Subjects:
systemic sclerosis
SFRP4
GVHD
fibrosis
wnt
caveolin-1
Online Access:https://www.mdpi.com/2077-0383/10/24/5820

Internet

https://www.mdpi.com/2077-0383/10/24/5820

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