Isoliensinine from Cissampelos pariera rhizomes exhibits potential gametocytocidal and anti-malarial activities against Plasmodium falciparum clinical isolates

Isoliensinine from Cissampelos pariera rhizomes exhibits potential gametocytocidal and anti-malarial activities against Plasmodium falciparum clinical isolates

Abstract Background The unmet demand for effective malaria transmission-blocking agents targeting the transmissible stages of Plasmodium necessitates intensive discovery efforts. In this study, a bioactive bisbenzylisoquinoline (BBIQ), isoliensinine, from Cissampelos pariera (Menispermaceae) rhizome...

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Bibliographic Details
Main Authors: Jackson M. Muema, James M. Mutunga, Meshack A. Obonyo, Merid N. Getahun, Ramadhan S. Mwakubambanya, Hoseah M. Akala, Agnes C. Cheruiyot, Redemptah A. Yeda, Dennis W. Juma, Ben Andagalu, Jaree L. Johnson, Amanda L. Roth, Joel L. Bargul
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Malaria Journal
Subjects:
Isoliensinine
Gametocytes
Plasmodium transmission-blocking
Cissampelos pariera
Malaria control
Natural product
Online Access:https://doi.org/10.1186/s12936-023-04590-7

Internet

https://doi.org/10.1186/s12936-023-04590-7

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