Identification of the Hepatic Metabolites of Flumazenil and their Kinetic Application in Neuroimaging

Identification of the Hepatic Metabolites of Flumazenil and their Kinetic Application in Neuroimaging

Studies of the neurobiological causes of anxiety disorders have suggested that the γ-aminobutyric acid (GABA) system increases synaptic concentrations and enhances the affinity of GABA<sub>A</sub> (type A) receptors for benzodiazepine ligands. Flumazenil antagonizes the benzodiazepine-bi...

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Bibliographic Details
Main Authors: Wei-Hsi Chen, Chuang-Hsin Chiu, Shiou-Shiow Farn, Kai-Hung Cheng, Yuan-Ruei Huang, Shih-Ying Lee, Yao-Ching Fang, Yu-Hua Lin, Kang-Wei Chang
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceuticals
Subjects:
flumazenil
LC-QqQ MS
metabolism
γ-aminobutyric acid receptor antagonist
benzodiazepine receptors
Online Access:https://www.mdpi.com/1424-8247/16/5/764

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https://www.mdpi.com/1424-8247/16/5/764

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