The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau

The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau

Tau35 is a truncated form of tau found in human brain in a subset of tauopathies. Tau35 expression in mice recapitulates key features of human disease, including progressive increase in tau phosphorylation, along with cognitive and motor dysfunction. The appearance of aggregated tau suggests that Ta...

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Bibliographic Details
Main Authors: Chen Lyu, Stefano Da Vela, Youssra Al-Hilaly, Karen E. Marshall, Richard Thorogate, Dmitri Svergun, Louise C. Serpell, Annalisa Pastore, Diane P. Hanger
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
biophysical studies
hybrid methods
tauopathy
tau truncation
small angle x-ray scattering
intrinsically disordered proteins
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.779240/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.779240/full

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