Role of integrin α4 in the inhibition of fibrosis in activated hepatic stellate cells by Periplaneta americana extract

Role of integrin α4 in the inhibition of fibrosis in activated hepatic stellate cells by Periplaneta americana extract

This study aims to investigate the role of integrin α4 (ITGA4) in the inhibition of hepatic stellate cells (HSCs) fibrosis by Periplaneta americana extract (PAE), as well as to explore its molecular mechanisms. In vitro experiments utilized TGFβ-induced LX2 and HSC-T6 cells to examine the anti-fibro...

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Bibliographic Details
Main Authors: Ying Fang, Ye Liu, Dingchun Li, Yi Miu, Kexuan Chen, Jv Zhou, Lijuan Xie, Xinting Chen, Jingyan Wu, Ying Zhu, Lechun Lv, Wu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
Periplaneta americana extract (PAE)
ITGA4
LX2
HSC-T6
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1517491/full

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https://www.frontiersin.org/articles/10.3389/fphar.2025.1517491/full

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