Resistance to 2-Hydroxy-Flutamide in Prostate Cancer Cells Is Associated with the Downregulation of Phosphatidylcholine Biosynthesis and Epigenetic Modifications

Resistance to 2-Hydroxy-Flutamide in Prostate Cancer Cells Is Associated with the Downregulation of Phosphatidylcholine Biosynthesis and Epigenetic Modifications

In this study, we examined the metabolic adaptations of a chemoresistant prostate cancer cell line in comparison to a sensitive cell line. We utilized prostate cancer LNCaP cells and subjected them to a stepwise increase in the antiandrogen 2-hydroxy-flutamide (FLU) concentration to generate a FLU-r...

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Bibliographic Details
Main Authors: José María Mora-Rodríguez, Belén G. Sánchez, Alba Sebastián-Martín, Alba Díaz-Yuste, Manuel Sánchez-Chapado, Ana María Palacín, Carlos Sánchez-Rodríguez, Alicia Bort, Inés Díaz-Laviada
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
LNCaP cells
flutamide
antiandrogens
dormant cells
phosphatidylcholine metabolism
resistant prostate cancer
Online Access:https://www.mdpi.com/1422-0067/24/21/15626

Internet

https://www.mdpi.com/1422-0067/24/21/15626

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