Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis

Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by the involvement of multiple organs. Lupus nephritis (LN) is a major risk factor for overall morbidity and mortality in SLE patients. Hence, designing effective drugs is pivotal for treating individuals w...

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Bibliographic Details
Main Authors: Shogo Ijima, Yuki Saito, Kentaro Nagaoka, Sena Yamamoto, Tsukasa Sato, Norihiro Miura, Taiki Iwamoto, Maki Miyajima, Takako S. Chikenji
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus (SLE)
lupus nephritis (LN)
senescence
transforming growth factor β (TGF-β)
p15INK4B
senolytic agent
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.960601/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.960601/full

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