Chronic allopurinol treatment during the last trimester of pregnancy in sows: effects on low and normal birth weight offspring.

Low-birth-weight (LBW) children are born with several risk factors for disease, morbidity and neonatal mortality, even if carried to term. Placental insufficiency leading to hypoxemia and reduced nutritional supply is the main cause for LBW. Brain damage and poor neurological outcome can be the cons...

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Main Authors: Elise T Gieling, Alexandra Antonides, Johanna Fink-Gremmels, Kim Ter Haar, Wikke I Kuller, Ellen Meijer, Rebecca E Nordquist, Jacomijn M Stouten, Elly Zeinstra, Franz Josef van der Staay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3899238?pdf=render