Apigenin modulates hippocampal CREB-BDNF signaling in high fat, high fructose diet-fed rats

Apigenin modulates hippocampal CREB-BDNF signaling in high fat, high fructose diet-fed rats

A high-calorie diet is associated with brain insulin resistance and neuronal dysfunction. Brain-derived neurotrophic factor (BDNF) plays a role in neurogenesis, cognitive functions and synaptic plasticity. Insulin resistance significantly alters BDNF levels which makes neurons vulnerable to degenera...

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Bibliographic Details
Main Authors: Jagan Kalivarathan, Kalpana Kalaivanan, Sathiya Priya Chandrasekaran, Dipti Nanda, Vidhya Ramachandran, Anuradha Carani Venkatraman
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Journal of Functional Foods
Subjects:
High fat, high fructose diet
Dipeptidyl peptidase-4
Brain-derived neurotrophic factor
Insulin resistance
Apigenin
Sitagliptin
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464620301225

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http://www.sciencedirect.com/science/article/pii/S1756464620301225

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