Effects of granulation process variables on the physical properties of dosage forms by combination of experimental design and principal component analysis

The current study was to understand how process variables of high shear wet granulations affect physical properties of granules and tablets. The knowledge gained was intended to be used for Quality-by-Design based process design and optimization. The variables were selected based on the risk assessm...

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Bibliographic Details
Main Authors: Prakash Thapa, Du Hyung Choi, Min Soo Kim, Seong Hoon Jeong
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Asian Journal of Pharmaceutical Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087618306731