MAP Kinase Phosphatase 3 (MKP3) Preserves Norepinephrine Transporter Activity by Modulating ERK1/2 Kinase-Mediated Gene Expression

MAP Kinase Phosphatase 3 (MKP3) Preserves Norepinephrine Transporter Activity by Modulating ERK1/2 Kinase-Mediated Gene Expression

The norepinephrine transporter (NET) mediates the clearance of norepinephrine (NE) from the extracellular space and is a target of therapeutic antidepressants and psychostimulants. Previously we identified a MAP kinase phosphatase 3 (MKP3), as an important modulator of protein kinase C (PKC) mediate...

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Bibliographic Details
Main Authors: Ole V. Mortensen, Mads B. Larsen, Susan G. Amara
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
caveolin
dual-specificity phosphoprotein phosphatase
extracellular-signal-regulated kinase (ERK)
mitogen-activated protein kinase (MAPK)
monoamine transporter
norepinephrine
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00253/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00253/full

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