A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro

A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro

Abstract Background Alzheimer’s disease (AD), the most common form of dementia, is a progressive neurodegenerative disorder that mainly affects older adults. One of the pathological hallmarks of AD is abnormally aggregated Tau protein that forms fibrillar deposits in the brain. In AD, Tau pathology...

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Bibliographic Details
Main Authors: Isabelle Aillaud, Senthilvelrajan Kaniyappan, Ram Reddy Chandupatla, Lisa Marie Ramirez, Sewar Alkhashrom, Jutta Eichler, Anselm H. C. Horn, Markus Zweckstetter, Eckhard Mandelkow, Heinrich Sticht, Susanne Aileen Funke
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Tau aggregation inhibitors
Phage display
D-amino acid peptides
Therapy
Online Access:https://doi.org/10.1186/s13195-022-00959-z

Internet

https://doi.org/10.1186/s13195-022-00959-z

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