Influence of Type 2 Diabetes in the Association of <i>PNPLA3</i> rs738409 and <i>TM6SF2</i> rs58542926 Polymorphisms in NASH Advanced Liver Fibrosis

Influence of Type 2 Diabetes in the Association of <i>PNPLA3</i> rs738409 and <i>TM6SF2</i> rs58542926 Polymorphisms in NASH Advanced Liver Fibrosis

Nonalcoholic steatohepatitis (NASH) is a leading cause of cirrhosis in western countries. Insulin resistance (IR), type 2 diabetes (T2D), and the polymorphisms patatin-like phospholipase domain-containing 3 (<i>PNPLA3</i>) rs738409 and transmembrane 6 superfamily member 2 (<i>TM6SF...

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Bibliographic Details
Main Authors: Pablo Gabriel-Medina, Roser Ferrer-Costa, Francisco Rodriguez-Frias, Andreea Ciudin, Salvador Augustin, Jesus Rivera-Esteban, Juan M. Pericàs, David Martinez Selva
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomedicines
Subjects:
nonalcoholic steatohepatitis (NASH)
advanced fibrosis
<i>PNPLA3</i> p.I148M
<i>TM6SF2</i> p.E167K
type 2 diabetes (T2D)
homeostatic model assessment for insulin resistance (HOMA-IR)
Online Access:https://www.mdpi.com/2227-9059/10/5/1015

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https://www.mdpi.com/2227-9059/10/5/1015

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