Preclinical study in a postoperative pain model to investigate the action of ketamine, lidocaine, and ascorbic acid in reversing fentanyl-induced, non–glutamate-dependent hyperalgesia

Abstract. Introduction:. Opioid-induced hyperalgesia (OIH) is a paradoxical phenomenon in which exposure to opioids can increase sensitivity to painful stimuli. Currently, several drugs have been used in an attempt to prevent OIH. We design this study to address the effect of preemptive treatment wi...

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Bibliographic Details
Main Authors: Marina Ayres Delgado, Luana Assis Ferreira, Bianka Jaciara dos Santos Gomes, Isis Katarine Orlandi Leite, Marcus Vinícius Gomez, Célio Castro-Junior
Format: Article
Language:English
Published: Wolters Kluwer 2023-04-01
Series:PAIN Reports
Online Access:http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001062