Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

Manual sample deposition on a substrate can introduce artifacts in quantitative AFM measurements. Here the authors present a microfluidic spray device for reliable deposition of subpicoliter droplets which dry out in milliseconds after landing on the surface, thereby avoiding protein self-assembly.

Bibliographic Details
Main Authors: Francesco Simone Ruggeri, Jerome Charmet, Tadas Kartanas, Quentin Peter, Sean Chia, Johnny Habchi, Christopher M. Dobson, Michele Vendruscolo, Tuomas P. J. Knowles
Format: Article
Language:English
Published: Nature Portfolio 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06345-4

Internet

https://doi.org/10.1038/s41467-018-06345-4

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