Characterization of Two Mouse <i>Chd7</i> Heterozygous Loss-of-Function Models Shows Dysgenesis of the Corpus Callosum and Previously Unreported Features of CHARGE Syndrome

Characterization of Two Mouse <i>Chd7</i> Heterozygous Loss-of-Function Models Shows Dysgenesis of the Corpus Callosum and Previously Unreported Features of CHARGE Syndrome

CHARGE syndrome is a rare congenital disorder frequently caused by mutations in the chromodomain helicase DNA-binding protein-7 <i>CHD7</i>. Here, we developed and systematically characterized two genetic mouse models with identical, heterozygous loss-of-function mutation of the <i>...

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Bibliographic Details
Main Authors: Stephan C. Collins, Valerie E. Vancollie, Anna Mikhaleva, Christel Wagner, Rebecca Balz, Christopher J. Lelliott, Binnaz Yalcin
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
neurodevelopmental disorders
CHARGE syndrome
dysgenesis of the corpus callosum
mouse models
CHD7
Online Access:https://www.mdpi.com/1422-0067/23/19/11509

Internet

https://www.mdpi.com/1422-0067/23/19/11509

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