Structural consequences of turnover-induced homocitrate loss in nitrogenase

Abstract Nitrogenase catalyzes the ATP-dependent reduction of dinitrogen to ammonia during the process of biological nitrogen fixation that is essential for sustaining life. The active site FeMo-cofactor contains a [7Fe:1Mo:9S:1C] metallocluster coordinated with an R-homocitrate (HCA) molecule. Here...

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Bibliographic Details
Main Authors: Rebeccah A. Warmack, Ailiena O. Maggiolo, Andres Orta, Belinda B. Wenke, James B. Howard, Douglas C. Rees
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36636-4