Distribution of Bacterial α1,3-Galactosyltransferase Genes in the Human Gut Microbiome

Distribution of Bacterial α1,3-Galactosyltransferase Genes in the Human Gut Microbiome

Because of a loss-of-function mutation in the GGTA1 gene, humans are unable to synthetize α1,3-Galactose (Gal) decorated glycans and develop high levels of circulating anti-α1,3-Galactose antibodies (anti-Gal Abs). Anti-Gal Abs have been identified as a major obstacle of organ xenotransplantation an...

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Bibliographic Details
Main Authors: Emmanuel Montassier, Gabriel A. Al-Ghalith, Camille Mathé, Quentin Le Bastard, Venceslas Douillard, Abel Garnier, Rémi Guimon, Bastien Raimondeau, Yann Touchefeu, Emilie Duchalais, Nicolas Vince, Sophie Limou, Pierre-Antoine Gourraud, David A. Laplaud, Arnaud B. Nicot, Jean-Paul Soulillou, Laureline Berthelot
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
intestinal microbiome
α1,3-Galactosyltransferase
α1,3-Gal antigen
shotgun data
enterobacteriaceae
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03000/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03000/full

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