Exosomal mRNAs for Angiogenic–Osteogenic Coupled Bone Repair

Exosomal mRNAs for Angiogenic–Osteogenic Coupled Bone Repair

Abstract Regenerative medicine in tissue engineering often relies on stem cells and specific growth factors at a supraphysiological dose. These approaches are costly and may cause severe side effects. Herein, therapeutic small extracellular vesicles (t‐sEVs) endogenously loaded with a cocktail of hu...

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Bibliographic Details
Main Authors: Yifan Ma, Lili Sun, Jingjing Zhang, Chi‐ling Chiang, Junjie Pan, Xinyu Wang, Kwang Joo Kwak, Hong Li, Renliang Zhao, Xilal Y. Rima, Chi Zhang, Anan Zhang, Yutong Liu, Zirui He, Derek Hansford, Eduardo Reategui, Changsheng Liu, Andrew S. Lee, Yuan Yuan, Ly James Lee
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Advanced Science
Subjects:
PEGylated poly (glycerol sebacate) acrylate (PEGS‐A) hydrogel
small extracellular vesicles carrying therapeutic mRNAs and associated microRNAs
track‐etched membrane‐based nanoelectroporation (TM‐nanoEP)
vascular endothelial growth factor A (VEGF‐A)
bone morphogenetic protein 2 (BMP‐2) mRNAs coupled angiogenic–osteogenic regeneration
Online Access:https://doi.org/10.1002/advs.202302622

Internet

https://doi.org/10.1002/advs.202302622

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