PPARδ Activation Mitigates 6-OHDA-Induced Neuronal Damage by Regulating Intracellular Iron Levels

PPARδ Activation Mitigates 6-OHDA-Induced Neuronal Damage by Regulating Intracellular Iron Levels

Intracellular iron accumulation in dopaminergic neurons contributes to neuronal cell death in progressive neurodegenerative disorders such as Parkinson’s disease. However, the mechanisms of iron homeostasis in this context remain incompletely understood. In the present study, we assessed the role of...

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Bibliographic Details
Main Authors: Won Jin Lee, Hyuk Gyoon Lee, Jinwoo Hur, Gyeong Hee Lee, Jun Pil Won, Eunsu Kim, Jung Seok Hwang, Han Geuk Seo
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Antioxidants
Subjects:
ferroptosis
6-hydroxydopamine
iron homeostasis
iron regulatory protein 1
peroxisome proliferator-activated receptor δ
Online Access:https://www.mdpi.com/2076-3921/11/5/810

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https://www.mdpi.com/2076-3921/11/5/810

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