Evaluation of the Novel Synthetic Tyrosinase Inhibitor (<i>Z</i>)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) <i>In Vitro</i> and <i>In Silico</i>

Evaluation of the Novel Synthetic Tyrosinase Inhibitor (<i>Z</i>)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) <i>In Vitro</i> and <i>In Silico</i>

Tyrosinase is a key enzyme in melanin synthesis, catalyzing the initial rate-limiting steps of melanin synthesis. Abnormal and excessive melanin synthesis is the primary cause of serious skin disorders including melasma, senile lentigo, freckles, and age spots. In attempts to find potent and safe ty...

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Bibliographic Details
Main Authors: EunJin Bang, Sang-Gyun Noh, Sugyeong Ha, Hee Jin Jung, Dae Hyun Kim, A Kyoung Lee, Min Kyung Hyun, Dongwan Kang, Sanggwon Lee, Chaeun Park, Hyung Ryong Moon, Hae Young Chung
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
(<i>Z</i>)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one
tyrosinase
<i>in silico</i> docking simulation
B16F10
α-melanocyte-stimulating hormone
Online Access:https://www.mdpi.com/1420-3049/23/12/3307

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https://www.mdpi.com/1420-3049/23/12/3307

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