Kinetic Optimization of the Batch Crystallization of an Active Pharmaceutical Ingredient in the Presence of a Low-Solubility, Precipitating Impurity

Kinetic Optimization of the Batch Crystallization of an Active Pharmaceutical Ingredient in the Presence of a Low-Solubility, Precipitating Impurity

The presence of impurities above regulatory thresholds has been responsible for recent recalls of pharmaceutical drugs. Crystallization is one of the most used separation processes to control impurities in the final drug. A particular issue emerges when impurities are poorly soluble in the crystalli...

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Bibliographic Details
Main Authors: Mitchell Paolello, Ilyes Bichari, Davinia Brouckaert, Mirvatte Francis, Dawn Yang, Gerard Capellades
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Crystals
Subjects:
crystallization
kinetics
impurities
Process Analytical Technologies (PAT)
Raman spectroscopy
modeling
Online Access:https://www.mdpi.com/2073-4352/13/11/1569

Internet

https://www.mdpi.com/2073-4352/13/11/1569

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