Development of a high sensitivity UHPLC-MS/MS method to determine the twelve compounds of Physochlainae Radix extract and application to a pharmacokinetic study in rats

Development of a high sensitivity UHPLC-MS/MS method to determine the twelve compounds of Physochlainae Radix extract and application to a pharmacokinetic study in rats

Physochlainae Radix (PR) is generally applied for treating cough and asthma. In this study, a sensitive ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-MS/MS) method was established and validated for the simultaneous determination of twelve compon...

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Bibliographic Details
Main Authors: Zhenguo Lv, Caixia Li, Tiantian Wu, Peng Zhao, Yang Liu, Huizi Ouyang, Jihong Feng, Jun He
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Arabian Journal of Chemistry
Subjects:
Physochlainae Radix
UHPLC-MS/MS
Pharmacokinetics
Rat plasma
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535224000662

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http://www.sciencedirect.com/science/article/pii/S1878535224000662

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