LGR4, a G Protein-Coupled Receptor With a Systemic Role: From Development to Metabolic Regulation

LGR4, a G Protein-Coupled Receptor With a Systemic Role: From Development to Metabolic Regulation

Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4/GPR48), a member of the GPCR (G protein-coupled receptors) superfamily, subfamily B, is a common intestinal crypt stem cell marker. It binds R-spondins/Norrin as classical ligands and plays a crucial role in Wnt signaling potentiation...

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Bibliographic Details
Main Authors: Joanna Filipowska, Nagesha G. Kondegowda, Nancy Leon-Rivera, Sangeeta Dhawan, Rupangi C. Vasavada
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Endocrinology
Subjects:
LGR4
GPCRs (G protein-coupled receptors)
Wnt signaling
RANKL (Receptor Activator for Nuclear Factor k B Ligand)
inflammation
NFκB - Nuclear Factor κB
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.867001/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.867001/full

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