A High-Throughput HIV-1 Drug Screening Platform, Based on Lentiviral Vectors and Compatible with Biosafety Level-1

A High-Throughput HIV-1 Drug Screening Platform, Based on Lentiviral Vectors and Compatible with Biosafety Level-1

HIV-1 infection is a complex, multi-step process involving not only viral, but also multiple cellular factors. To date, drug discovery methods have primarily focused on the inhibition of single viral proteins. We present an efficient and unbiased approach, compatible with biosafety level 1 (BSL-1) c...

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Bibliographic Details
Main Authors: Bernhard Ellinger, Daniel Pohlmann, Jannis Woens, Felix M. Jäkel, Jeanette Reinshagen, Carol Stocking, Vladimir S. Prassolov, Boris Fehse, Kristoffer Riecken
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Viruses
Subjects:
HIV-1 drug development
BSL-1 screening platform
high-throughput screening
lentiviral vectors
mCat1 expressing PM1 T cell line
LeGO vectors
Online Access:https://www.mdpi.com/1999-4915/12/5/580

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https://www.mdpi.com/1999-4915/12/5/580

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