Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

Abstract Background Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indispensable role, however, its mechanism of action (MoA) is not fully und...

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Main Authors: Peng Gao, Yan-Qing Liu, Wei Xiao, Fei Xia, Jia-Yun Chen, Li-Wei Gu, Fan Yang, Liu-Hai Zheng, Jun-Zhe Zhang, Qian Zhang, Zhi-Jie Li, Yu-Qing Meng, Yong-Ping Zhu, Huan Tang, Qiao-Li Shi, Qiu-Yan Guo, Ying Zhang, Cheng-Chao Xu, Ling-Yun Dai, Ji-Gang Wang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Military Medical Research
Subjects:
Chloroquine
Antimalaria
Activity-based protein profiling (ABPP)
Cellular thermal shift assay (CETSA)
Quantitative proteomics
Online Access:https://doi.org/10.1186/s40779-022-00390-3

Internet

https://doi.org/10.1186/s40779-022-00390-3

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