Spontaneous improvement in randomised clinical trials: meta-analysis of three-armed trials comparing no treatment, placebo and active intervention

Spontaneous improvement in randomised clinical trials: meta-analysis of three-armed trials comparing no treatment, placebo and active intervention

<p>Abstract</p> <p>Background</p> <p>It can be challenging for patients and clinicians to properly interpret a change in the clinical condition after a treatment has been given. It is not known to which extent spontaneous improvement, effect of placebo and effect of act...

Full description

Bibliographic Details
Main Authors:	Gøtzsche Peter C, Hróbjartsson Asbjørn, Krogsbøll Lasse
Format:	Article
Language:	English
Published:	BMC 2009-01-01
Series:	BMC Medical Research Methodology
Online Access:	http://www.biomedcentral.com/1471-2288/9/1

Similar Items

Sponsors’ participation in conduct and reporting of industry trials: a descriptive study
by: Lundh Andreas, et al.
Published: (2012-08-01)

Conflicts of interest at medical journals: the influence of industry-supported randomised trials on journal impact factors and revenue - cohort study.
by: Andreas Lundh, et al.
Published: (2010-10-01)

Ghost authorship in industry-initiated randomised trials.
by: Peter C Gøtzsche, et al.
Published: (2007-01-01)

Ghost authorship in industry-initiated randomised trials.
by: Gøtzsche, P, et al.
Published: (2007)

Discrepancies in sample size calculations and data analyses reported in randomised trials: comparison of publications with protocols.
by: Chan, A, et al.
Published: (2008)

Efficacy of antidepressants over placebo is similar in two-armed versus three-armed or more-armed randomized placebo-controlled trials.
by: Ogawa, Y, et al.
Published: (2017)

Promoting public access to clinical trial protocols: challenges and recommendations
by: An-Wen Chan, et al.
Published: (2018-02-01)

Feasibility of surgical randomised controlled trials with a placebo arm: a systematic review
by: Wartolowska, K, et al.
Published: (2016)

Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials.
by: Pildal, J, et al.
Published: (2007)

Better to be in The Placebo Arm for Trials of Neurological Therapies?
by: Jonathan Kimmelman
Published: (2018-04-01)

Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis
by: Christian Gluud, et al.
Published: (2022-06-01)

Duloxetine versus ‘active’ placebo, placebo or no intervention for major depressive disorder; a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
by: Faiza Siddiqui, et al.
Published: (2021-06-01)

Impact of placebo arms on outcomes in antidepressant trials: systematic review and meta-regression analysis
by: Salanti, G, et al.
Published: (2018)

Open-Label Three Arm Trial Comparing Ormeloxifene, Gamma Linolenic Acid With Methylcobalamine + Vitamin C and Placebo in Mastalgia
by: Amrendra Verma, et al.
Published: (2022-07-01)

Is laparoscopic excision for superficial peritoneal endometriosis helpful or harmful? Protocol for a double-blinded, randomised, placebo-controlled, three-armed surgical trial
by: Ulrik Schiøler Kesmodel, et al.
Published: (2022-11-01)

Optimising the design and delivery of placebo surgical interventions in randomised controlled trials: The DITTO framework
by: Cousins, S, et al.
Published: (2019)

Incentives in Diabetic Eye Assessment by Screening (IDEAS) trial: a three-armed randomised controlled trial of financial incentives
by: Gaby Judah, et al.
Published: (2017-03-01)

The importance of using placebo controls in nonpharmacological randomised trials
by: Wartolowska, KA, et al.
Published: (2022)

Ethical considerations in placebo-controlled randomised clinical trials
by: Kenneth R. Kaufman
Published: (2015-06-01)

Comparative efficacy of placebos in short-term antidepressant trials for major depression: a secondary meta-analysis of placebo-controlled trials
by: Lisa Holper, et al.
Published: (2020-09-01)

A meta-analysis of temporal changes of response in the placebo arm of surgical randomized controlled trials: an update
by: Wartolowska, KA, et al.
Published: (2017)

A meta-analysis of temporal changes of response in the placebo arm of surgical randomized controlled trials: an update
by: Karolina A. Wartolowska, et al.
Published: (2017-07-01)

Constraints on publication rights in industry-initiated clinical trials.
by: Gøtzsche, P, et al.
Published: (2006)

Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles.
by: Chan, A, et al.
Published: (2004)

Optimal trial design selection: a comparative analysis between two-arm and three-arm trials incorporating network meta-analysis for evaluating a new treatment
by: Fangshu Ye, et al.
Published: (2023-11-01)

The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months
by: Duley, L, et al.
Published: (2007)

The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for women at 2 years
by: Duley, L, et al.
Published: (2007)

Screening and brief intervention for obesity in primary care: a parallel, two-arm, randomised trial
by: Aveyard, P, et al.
Published: (2016)

Screening and brief intervention for obesity in primary care: a parallel, two-arm, randomised trial.
by: Aveyard, P, et al.
Published: (2016)

Randomised controlled trials may underestimate drug effects: balanced placebo trial design.
by: Karen Lund, et al.
Published: (2014-01-01)

Randomised placebo-controlled trials of surgery – ethical analysis and guidelines
by: Savulescu, J, et al.
Published: (2016)

Incorporating single-arm studies in meta-analysis of randomised controlled trials: a simulation study
by: Janharpreet Singh, et al.
Published: (2021-06-01)

Effect of osteosynthesis, primary hemiarthroplasty, and non-surgical management for displaced four-part fractures of the proximal humerus in elderly: a multi-centre, randomised clinical trial
by: Johannsen Hans, et al.
Published: (2009-07-01)

Empirical Evidence of Study Design Biases in Randomized Trials: Systematic Review of Meta-Epidemiological Studies.
by: Matthew J Page, et al.
Published: (2016-01-01)

A pragmatic cluster randomised trial evaluating three implementation interventions
by: Rycroft-Malone Jo, et al.
Published: (2012-08-01)

Reporting on blinding in trial protocols and corresponding publications was often inadequate but rarely contradictory.
by: Hróbjartsson, A, et al.
Published: (2009)

Comparison of descriptions of allocation concealment in trial protocols and the published reports: cohort study.
by: Pildal, J, et al.
Published: (2005)

Effects of the peripherally acting μ-opioid receptor antagonist methylnaltrexone on acute pancreatitis severity: study protocol for a multicentre double-blind randomised placebo-controlled interventional trial, the PAMORA-AP trial
by: Cecilie Siggaard Knoph, et al.
Published: (2021-12-01)

The microbiome of infants recruited to a randomised placebo-controlled probiotic trial (PiPS Trial)
by: Millar, M, et al.
Published: (2017)

The Microbiome of Infants Recruited to a Randomised Placebo-controlled Probiotic Trial (PiPS Trial)
by: Michael Millar, et al.
Published: (2017-06-01)