Mitochondrial fusion is required for spermatogonial differentiation and meiosis

Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis. Acutely after depletion of mitofusins Mfn1 and Mfn2, spermatogenesis arrests due to failure to accomplish a meta...

Full description

Bibliographic Details
Main Authors: Grigor Varuzhanyan, Rebecca Rojansky, Michael J Sweredoski, Robert LJ Graham, Sonja Hess, Mark S Ladinsky, David C Chan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/51601