Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling PathwaySummary

Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling PathwaySummary

Background & Aims: Sustained c-Jun N-terminal kinase (JNK) activation plays a major role in drug-induced liver injury (DILI). Stress-responsive microRNA-31 (miR-31) has been implicated in regulating different cellular damage, and JNK activation could induce miR-31 expression. However, the re...

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Bibliographic Details
Main Authors: Jianxin Zheng, Hong Zhou, Taihua Yang, Jinchuan Liu, Tian Qin, Xiangqian Gu, Ji Wu, Yi Zhang, Honglin Wang, Yuanjia Tang, Feng Xue, Yimin Mao, Qiang Xia
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
microRNA
Drug-Induced Liver Injury
Damage Responsive
Negative Feedback
Necrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X21001569

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http://www.sciencedirect.com/science/article/pii/S2352345X21001569

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