Striated myocyte structural integrity: Automated analysis of sarcomeric z-discs.

As sarcomeres produce the force necessary for contraction, assessment of sarcomere order is paramount in evaluation of cardiac and skeletal myocytes. The uniaxial force produced by sarcomeres is ideally perpendicular to their z-lines, which couple parallel myofibrils and give cardiac and skeletal my...

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Bibliographic Details
Main Authors: Tessa Altair Morris, Jasmine Naik, Kirby Sinclair Fibben, Xiangduo Kong, Tohru Kiyono, Kyoko Yokomori, Anna Grosberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-03-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007676