Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations

Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations

Xist RNA is required for X chromosome inactivation but it is not well understood how Xist silences some regions more efficiently than others. Here, the authors induce ectopic Xist expression from multiple different X-linked and autosomal loci in cells to explore Xist function.

Bibliographic Details
Main Authors: Agnese Loda, Johannes H. Brandsma, Ivaylo Vassilev, Nicolas Servant, Friedemann Loos, Azadeh Amirnasr, Erik Splinter, Emmanuel Barillot, Raymond A. Poot, Edith Heard, Joost Gribnau
Format: Article
Language:English
Published: Nature Portfolio 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00528-1

Internet

https://doi.org/10.1038/s41467-017-00528-1

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