HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells

HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells

Abstract Background Hypoxia stimulates metastasis in cancer and is linked to poor patient prognosis. In tumours, oxygen levels vary and hypoxic regions exist within a generally well-oxygenated tumour. However, whilst the heterogeneous environment is known to contribute to metastatic progression, lit...

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Bibliographic Details
Main Authors: Hannah Harrison, Henry J. Pegg, Jamie Thompson, Christian Bates, Paul Shore
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Cancer
Subjects:
Breast cancer
HIF-alpha
Hypoxia
Tumour micro-environment
Co-culture
Online Access:http://link.springer.com/article/10.1186/s12885-018-4577-1

Internet

http://link.springer.com/article/10.1186/s12885-018-4577-1

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