Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells.

Transient cell therapy is an emerging drug class that requires new approaches for pharmacological monitoring during use. Human mesenchymal stem cells (MSCs) are a clinically-tested transient cell therapeutic that naturally secrete anti-inflammatory factors to attenuate immune-mediated diseases. MSCs...

Full description

Bibliographic Details
Main Authors: Jessica S Elman, Ryan C Murray, Fangjing Wang, Keyue Shen, Shan Gao, Kevin E Conway, Martin L Yarmush, Bakhos A Tannous, Ralph Weissleder, Biju Parekkadan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24587097/?tool=EBI