Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease

Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease

Abstract Neurogenesis, crucial for brain resilience, is reduced in Alzheimer’s disease (AD) that induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring neurogenesis could counteract neurodegenerative pathology. However, the molecular mechanisms promoting pro-neur...

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Bibliographic Details
Main Authors: Tohid Siddiqui, Mehmet Ilyas Cosacak, Stanislava Popova, Prabesh Bhattarai, Elanur Yilmaz, Annie J. Lee, Yuhao Min, Xue Wang, Mariet Allen, Özkan İş, Zeynep Tansu Atasavum, Natalia Rodriguez-Muela, Badri N. Vardarajan, Delaney Flaherty, Andrew F. Teich, Ismael Santa-Maria, Uwe Freudenberg, Carsten Werner, Giuseppe Tosto, Richard Mayeux, Nilüfer Ertekin-Taner, Caghan Kizil
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-023-00311-5

Internet

https://doi.org/10.1038/s41536-023-00311-5

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