BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer

BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer subtype often treated with radiotherapy (RT). Due to its intrinsic heterogeneity and lack of effective targets, it is crucial to identify novel molecular targets that would increase RT efficacy. Her...

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Bibliographic Details
Main Authors: Sushmitha Sriramulu, Shivani Thoidingjam, Wei-Min Chen, Oudai Hassan, Farzan Siddiqui, Stephen L. Brown, Benjamin Movsas, Michael D. Green, Anthony J. Davis, Corey Speers, Eleanor Walker, Shyam Nyati
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
BUB1
DNA damage response
Radiation sensitization
NHEJ
DNAPK
TNBC
Online Access:https://doi.org/10.1186/s13046-024-03086-9

Internet

https://doi.org/10.1186/s13046-024-03086-9

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