Stimulation of mTOR-independent autophagy and mitophagy by rilmenidine exacerbates the phenotype of transgenic TDP-43 mice

Stimulation of mTOR-independent autophagy and mitophagy by rilmenidine exacerbates the phenotype of transgenic TDP-43 mice

Autophagy, which mediates the delivery of cytoplasmic substrates to the lysosome for degradation, is essential for maintaining proper cell homeostasis in physiology, ageing, and disease. There is increasing evidence that autophagy is defective in neurodegenerative disorders, including motor neurons...

Full description

Bibliographic Details
Main Authors: Nirma D. Perera, Doris Tomas, Nayomi Wanniarachchillage, Brittany Cuic, Sophia J. Luikinga, Valeria Rytova, Bradley J. Turner
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
ALS
Autophagy
Motor neuron
Rilmenidine
TDP-43
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612100108X

Internet

http://www.sciencedirect.com/science/article/pii/S096999612100108X

Similar Items