Hemostatic potential of recombinant von Willebrand factor and standard or pegylated extended half-life recombinant factor VIII on thrombus formation under high shear flow

Hemostatic potential of recombinant von Willebrand factor and standard or pegylated extended half-life recombinant factor VIII on thrombus formation under high shear flow

Abstract Background Von Willebrand factor (VWF) and factor VIII (FVIII) complex play a pivotal role in hemostasis. A deficiency or defect of VWF causes von Willebrand disease (VWD). Recombinant (r)VWF product has proved to be effective for hemostatic treatment of VWD, but limited information is avai...

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Bibliographic Details
Main Authors: Hiroaki Yaoi, Yasuaki Shida, Kenichi Ogiwara, Keiji Nogami
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Thrombosis Journal
Subjects:
Von Willebrand disease
Von Willebrand factor
Factor VIII
Shear stress
Thrombus formation
Online Access:https://doi.org/10.1186/s12959-023-00569-1

Internet

https://doi.org/10.1186/s12959-023-00569-1

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