SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron

SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron

Summary: The coronavirus nucleocapsid (N) protein is known to bind to nucleic acids and facilitate viral genome encapsulation. Here we report that the N protein can mediate RNA or DNA entering neighboring cells through ACE2-independent, receptor (STEAP2)-mediated endocytosis, and achieve gene expres...

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Bibliographic Details
Main Authors: Jung-Lin Wu, I.-I. Kuan, Jing-You Guo, Wei-Chia Hsu, Wei-Chun Tang, Hsin-Ju Chan, Yu-Ju Chen, Bi-Chang Chen, Han-Chung Wu, James C. Liao
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Virology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422300072X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422300072X

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