In-silico investigation of systematic missense mutations of middle east respiratory coronavirus spike protein

In-silico investigation of systematic missense mutations of middle east respiratory coronavirus spike protein

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causes severe pneumonia-like symptoms and is still pose a significant threat to global public health. A key component in the virulence of MERS-CoV is the Spike (S) protein, which binds with the host membrane receptor dipeptidyl peptidase 4 (DPP...

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Bibliographic Details
Main Authors: Raina Rhoades, Adebiyi Sobitan, Vidhyanand Mahase, Brhan Gebremedhin, Qiyi Tang, Danda Rawat, Hongbao Cao, Shaolei Teng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
MERS-CoV
SARS-CoV-2
computational saturation mutagenesis
spike missense mutations
protein stability
S-DPP4 binding affinity
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.933553/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.933553/full

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