In-silico investigation of systematic missense mutations of middle east respiratory coronavirus spike protein

In-silico investigation of systematic missense mutations of middle east respiratory coronavirus spike protein

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causes severe pneumonia-like symptoms and is still pose a significant threat to global public health. A key component in the virulence of MERS-CoV is the Spike (S) protein, which binds with the host membrane receptor dipeptidyl peptidase 4 (DPP...

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Bibliographic Details
Main Authors:	Raina Rhoades, Adebiyi Sobitan, Vidhyanand Mahase, Brhan Gebremedhin, Qiyi Tang, Danda Rawat, Hongbao Cao, Shaolei Teng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Series:	Frontiers in Molecular Biosciences
Subjects:	MERS-CoV SARS-CoV-2 computational saturation mutagenesis spike missense mutations protein stability S-DPP4 binding affinity
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.933553/full

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