In Silico Analysis of Tetrodotoxin Binding in Voltage-Gated Sodium Ion Channels from Toxin-Resistant Animal Lineages

In Silico Analysis of Tetrodotoxin Binding in Voltage-Gated Sodium Ion Channels from Toxin-Resistant Animal Lineages

Multiple animal species have evolved resistance to the neurotoxin tetrodotoxin (TTX) through changes in voltage-gated sodium ion channels (VGSCs). Amino acid substitutions in TTX-resistant lineages appear to be positionally convergent with changes in homologous residues associated with reductions in...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Shana L. Geffeney, Jennie Ann Cordingley, Kenyon Mitchell, Charles T. Hanifin
Format: Artykuł
Język:English
Wydane: MDPI AG 2022-11-01
Seria:Marine Drugs
Hasła przedmiotowe:
marine toxin
voltage-gated ion channels
structure
tetrodotoxin
TTX
toxin resistance
Dostęp online:https://www.mdpi.com/1660-3397/20/11/723

Internet

https://www.mdpi.com/1660-3397/20/11/723

Podobne zapisy