In Silico Analysis of Tetrodotoxin Binding in Voltage-Gated Sodium Ion Channels from Toxin-Resistant Animal Lineages

In Silico Analysis of Tetrodotoxin Binding in Voltage-Gated Sodium Ion Channels from Toxin-Resistant Animal Lineages

Multiple animal species have evolved resistance to the neurotoxin tetrodotoxin (TTX) through changes in voltage-gated sodium ion channels (VGSCs). Amino acid substitutions in TTX-resistant lineages appear to be positionally convergent with changes in homologous residues associated with reductions in...

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Bibliographic Details
Main Authors: Shana L. Geffeney, Jennie Ann Cordingley, Kenyon Mitchell, Charles T. Hanifin
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Marine Drugs
Subjects:
marine toxin
voltage-gated ion channels
structure
tetrodotoxin
TTX
toxin resistance
Online Access:https://www.mdpi.com/1660-3397/20/11/723

Internet

https://www.mdpi.com/1660-3397/20/11/723

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