Dimensionality reduction methods for extracting functional networks from large‐scale CRISPR screens

Dimensionality reduction methods for extracting functional networks from large‐scale CRISPR screens

Abstract CRISPR‐Cas9 screens facilitate the discovery of gene functional relationships and phenotype‐specific dependencies. The Cancer Dependency Map (DepMap) is the largest compendium of whole‐genome CRISPR screens aimed at identifying cancer‐specific genetic dependencies across human cell lines. A...

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Bibliographic Details
Main Authors: Arshia Zernab Hassan, Henry N Ward, Mahfuzur Rahman, Maximilian Billmann, Yoonkyu Lee, Chad L Myers
Format: Article
Language:English
Published: Springer Nature 2023-11-01
Series:Molecular Systems Biology
Subjects:
auto‐encoder
gene co‐essentiality network
normalization
robust principal component analysis
unsupervised dimensionality reduction
Online Access:https://doi.org/10.15252/msb.202311657

Internet

https://doi.org/10.15252/msb.202311657

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