Heterogeneity of Genotype–Phenotype in Congenital Hypofibrinogenemia—A Review of Case Reports Associated with Bleeding and Thrombosis

Heterogeneity of Genotype–Phenotype in Congenital Hypofibrinogenemia—A Review of Case Reports Associated with Bleeding and Thrombosis

Congenital fibrinogen disorders are diseases associated with a bleeding tendency; however, there are also reports of thrombotic events. Fibrinogen plays a role in the pathogenesis of thrombosis due to altered plasma concentrations or modifications to fibrinogen’s structural properties, which affect...

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Bibliographic Details
Main Authors: Monika Brunclikova, Tomas Simurda, Jana Zolkova, Miroslava Sterankova, Ingrid Skornova, Miroslava Dobrotova, Zuzana Kolkova, Dusan Loderer, Marian Grendar, Jan Hudecek, Jan Stasko, Peter Kubisz
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Journal of Clinical Medicine
Subjects:
fibrinogen
hypofibrinogenemia
heterogeneity of phenotype
mutations associated with bleeding and thrombosis
Online Access:https://www.mdpi.com/2077-0383/11/4/1083

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https://www.mdpi.com/2077-0383/11/4/1083

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