Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation

Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation

Abstract Background Uncovering mechanisms of epigenome evolution is an essential step towards understanding the evolution of different cellular phenotypes. While studies have confirmed DNA methylation as a conserved epigenetic mechanism in mammalian development, little is known about the conservatio...

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Bibliographic Details
Main Authors: Jia Zhou, Renee L. Sears, Xiaoyun Xing, Bo Zhang, Daofeng Li, Nicole B. Rockweiler, Hyo Sik Jang, Mayank N.K. Choudhary, Hyung Joo Lee, Rebecca F. Lowdon, Jason Arand, Brianne Tabers, C. Charles Gu, Theodore J. Cicero, Ting Wang
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Genomics
Subjects:
DNA methylation
Epigenetic conservation
Tissue-specific
Comparative genomics
Comparative epigenomics
Online Access:http://link.springer.com/article/10.1186/s12864-017-4115-6

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http://link.springer.com/article/10.1186/s12864-017-4115-6

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