Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease

Therapeutic failure of benznidazole (BZ) is widely documented in Chagas disease and has been primarily associated with variations in the drug susceptibility of Trypanosoma cruzi strains. In humans, therapeutic success has been assessed by the negativation of anti-T. cruzi antibodies, a process that...

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Bibliographic Details
Main Authors: Margoth Moreno, Daniella A D'ávila, Marcelo N Silva, Lúcia MC Galvão, Andrea M Macedo, Egler Chiari, Eliane D Gontijo, Bianca Zingales
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2010-11-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000700014