Flavonoids extract from Rosa roxburghii fruit ameliorates carrageenan-induced thrombosis in mice
The fruits of Rosa roxburghii contain a high amount of flavonoids. We conducted a study using a carrageenan-induced thrombus model to investigate how Rosa roxburghii fruit flavonoids (RF) inhibit thrombosis using methods such as ELISA and 16S. The results showed that RF intervention reduced the leng...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623003857 |
| _version_ | 1797660399290548224 |
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| author | Xian Pu Yun Tao Jienan Lou Guanglei Lu Haoran Xu Shuming Tan Guofang Xie |
| author_facet | Xian Pu Yun Tao Jienan Lou Guanglei Lu Haoran Xu Shuming Tan Guofang Xie |
| author_sort | Xian Pu |
| collection | DOAJ |
| description | The fruits of Rosa roxburghii contain a high amount of flavonoids. We conducted a study using a carrageenan-induced thrombus model to investigate how Rosa roxburghii fruit flavonoids (RF) inhibit thrombosis using methods such as ELISA and 16S. The results showed that RF intervention reduced the length of the black tail in mice and controlled four hemagglutination parameters. Furthermore, RF treatment effectively reduced oxidative stress and inflammatory cytokines in the serum and tissues. RF also significantly inhibited platelet aggregation and promoted the synthesis of anticoagulant proteins. Pathological observations revealed that RF effectively alleviated tissue lesions and thrombosis. Through Western blot and qPCR analysis, we found that RF reduced inflammation by suppressing the NF-κB pathway in mice with thrombosis. The analysis of intestinal flora in mice, further revealed that RF intervention reduced the abundance of Bacteroides and Clostridium. Overall, these findings indicate that RF has biological activity in preventing carrageenan-induced thrombosis. |
| first_indexed | 2024-03-11T18:29:14Z |
| format | Article |
| id | doaj.art-bed703bacd8e4f8ca99e03fc95b432f4 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-11T18:29:14Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-bed703bacd8e4f8ca99e03fc95b432f42023-10-13T13:52:51ZengElsevierJournal of Functional Foods1756-46462023-10-01109105785Flavonoids extract from Rosa roxburghii fruit ameliorates carrageenan-induced thrombosis in miceXian Pu0Yun Tao1Jienan Lou2Guanglei Lu3Haoran Xu4Shuming Tan5Guofang Xie6School of Liquor and Food Engineering, Guizhou University, Guiyang, Guizhou Province 550025, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang, Guizhou Province 550025, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang, Guizhou Province 550025, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang, Guizhou Province 550025, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang, Guizhou Province 550025, ChinaCorresponding author.; School of Liquor and Food Engineering, Guizhou University, Guiyang, Guizhou Province 550025, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang, Guizhou Province 550025, ChinaThe fruits of Rosa roxburghii contain a high amount of flavonoids. We conducted a study using a carrageenan-induced thrombus model to investigate how Rosa roxburghii fruit flavonoids (RF) inhibit thrombosis using methods such as ELISA and 16S. The results showed that RF intervention reduced the length of the black tail in mice and controlled four hemagglutination parameters. Furthermore, RF treatment effectively reduced oxidative stress and inflammatory cytokines in the serum and tissues. RF also significantly inhibited platelet aggregation and promoted the synthesis of anticoagulant proteins. Pathological observations revealed that RF effectively alleviated tissue lesions and thrombosis. Through Western blot and qPCR analysis, we found that RF reduced inflammation by suppressing the NF-κB pathway in mice with thrombosis. The analysis of intestinal flora in mice, further revealed that RF intervention reduced the abundance of Bacteroides and Clostridium. Overall, these findings indicate that RF has biological activity in preventing carrageenan-induced thrombosis.http://www.sciencedirect.com/science/article/pii/S1756464623003857Rosa roxburghii fruitThrombosisNF-κBGut microbiota |
| spellingShingle | Xian Pu Yun Tao Jienan Lou Guanglei Lu Haoran Xu Shuming Tan Guofang Xie Flavonoids extract from Rosa roxburghii fruit ameliorates carrageenan-induced thrombosis in mice Journal of Functional Foods Rosa roxburghii fruit Thrombosis NF-κB Gut microbiota |
| title | Flavonoids extract from Rosa roxburghii fruit ameliorates carrageenan-induced thrombosis in mice |
| title_full | Flavonoids extract from Rosa roxburghii fruit ameliorates carrageenan-induced thrombosis in mice |
| title_fullStr | Flavonoids extract from Rosa roxburghii fruit ameliorates carrageenan-induced thrombosis in mice |
| title_full_unstemmed | Flavonoids extract from Rosa roxburghii fruit ameliorates carrageenan-induced thrombosis in mice |
| title_short | Flavonoids extract from Rosa roxburghii fruit ameliorates carrageenan-induced thrombosis in mice |
| title_sort | flavonoids extract from rosa roxburghii fruit ameliorates carrageenan induced thrombosis in mice |
| topic | Rosa roxburghii fruit Thrombosis NF-κB Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623003857 |
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