Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains

Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains

Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for therapeutic targeting in human diseases. We have developed a directed evolution platform c...

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Bibliographic Details
Main Authors: Steven D. Levin, Lawrence S. Evans, Susan Bort, Erika Rickel, Katherine E. Lewis, Rebecca P. Wu, Joseph Hoover, Sean MacNeil, David La, Martin F. Wolfson, Mark W. Rixon, Stacey R. Dillon, Michael G. Kornacker, Ryan Swanson, Stanford L. Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
costimulation
protein engineering
protein therapeutics
anti-inflammatory
IgSF
ICOS ligand (ICOSL)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03086/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03086/full

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